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Small Molecules Preselection

While our previously developed Resonant Recognition Model, was able to calculate resonant recognition and interaction frequencies for linear macromolecules like proteins, DNA and RNA, the biggest challenge is how to calculate resonant recognition and interaction frequencies between small molecules and linear macromolecules like proteins. It is well known that small molecules also selectively interact with proteins and thus, we have extended the idea of Resonant Recognition Model to small molecules proposing that such selective interactions between small molecules and proteins are also based on resonant energy transfer. For that purpose, we propose that energies of free electrons in small molecules are the most relevant for such resonant energy transfer.

This approach can be used for preselection of small molecules that can interact with protein receptors.


  1. Cosic I, Cosic D, Loncarevic I: New Concept of Small Molecules Interaction with Proteins – An Application to Potential COVID-19 Drugs. International Journal of Sciences, 2020, 9(9), 16-25, doi: 10.18483/ijSci.2390.

  2. Cosic I, Cosic D, Loncarevic I: Analysis of Ivermectin as Potential Inhibitor of SARS-CoV-2 Using Resonant Recognition Model. International Journal of Sciences, 2021, 10(1), 1-6, doi: 10.18483/ijSci.2433.


interaction between glutamate 

and glutamate receptor

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